InterPro domain: IPR026610

General Information

  • Identifier IPR026610
  • Description 3'-RNA ribose 2'-O-methyltransferase, Hen1

Abstract

This entry consists of the eukaryal and bacterial 3'-RNA ribose 2'-O-methyltransferase, Hen1. Eukaryal Hen1 is a methyltransferase that adds a 2'-O-methyl group at the 3'-end small RNAs to protects the 3'-end of sRNAs from uridylation activity and subsequent degradation [ 1 ]. In bacetria, Hen1 catalyses the same chemical reaction, but forms Pnkp/Hen1 heterotetramer and is involved in RNA repair [ 2 , 3 ].


1. Target RNA-directed trimming and tailing of small silencing RNAs. Science 328, 1534-9
2. Bacterial Hen1 is a 3' terminal RNA ribose 2'-O-methyltransferase component of a bacterial RNA repair cassette. RNA 16, 316-23
3. Reconstituting bacterial RNA repair and modification in vitro. Science 326, 247

Species distribution

Gene table