InterPro domain: IPR026591

The catalytic core of sirtuin proteins consists of a large and a small domains. The large domain has a Rossmann fold and binds NAD+. The small domain is composed of residues from two insertions in the Rossmann fold that form a helical and a zinc binding modules [ 1 , 2 ]. This superfamily represents the catalytic core small domain.

1. Crystal structure of a SIR2 homolog-NAD complex. Cell 105, 269-79
2. Structure of a Sir2 enzyme bound to an acetylated p53 peptide. Mol. Cell 10, 523-35