InterPro domain: IPR026533

This entry represents a domain found in non-canonical purine NTP phosphatases and in PRRC1 (proline-rich and coiled-coil-containing protein 1). These phosphatases hydrolyse non-canonical purine nucleotides such as XTP and ITP to their respective diphosphates derivatives [ 1 ]. PRRC1 is a Golgi-associated protein of unknown function [ 2 ].

1. Identification of an ITPase/XTPase in Escherichia coli by structural and biochemical analysis. Structure 13, 1511-20
2. Structural analysis and expression profile of a novel gene on chromosome 5q23 encoding a Golgi-associated protein with six splice variants, and involved within the 5q deletion of a Ph(-) CML patient. Leuk. Res. 29, 17-31