InterPro domain: IPR026506

GDP-D-glucose phosphorylase 1 (GDPGP1) is a specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells [ 1 ]. This family also includes the GDP-L-galactose/GDP-D-glucose phosphorylases VTC2 and VTC2L (VTC5) from Arabidopsis, which use preferentially GDP-L-galactose and GDP-D-glucose as substrates and are part of the Smirnoff-Wheeler pathway for ascorbate biosynthesis in plants [ 2 , 3 ].

This entry also includes uncharacterized proteins from bacteria.

1. A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals. J. Biol. Chem. 286, 21511-23
2. Arabidopsis VTC2 encodes a GDP-L-galactose phosphorylase, the last unknown enzyme in the Smirnoff-Wheeler pathway to ascorbic acid in plants. J. Biol. Chem. 282, 18879-85
3. A second GDP-L-galactose phosphorylase in arabidopsis en route to vitamin C. Covalent intermediate and substrate requirements for the conserved reaction. J. Biol. Chem. 283, 18483-92