InterPro domain: IPR026316

General Information

  • Identifier IPR026316
  • Description KAT8 regulatory NSL complex subunit 2
  • Number of genes 215
  • Gene duplication stats Loading...
  • Associated GO terms GO:0000123  

Abstract

The nonspecific lethal (NSL) complex associates with the histone acetyltransferase MOF (KAT8) in both Drosophila and mammals [ 1 ]. KAT8 regulatory NSL complex subunit 2 (KANSL2 or NSL2) is part of the NSL complex , which is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription [ 2 ].


1. The nonspecific lethal complex is a transcriptional regulator in Drosophila. Mol. Cell 38, 827-41
2. Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. J. Biol. Chem. 285, 4268-72

Species distribution

Gene table