InterPro domain: IPR026258
General Information
- Identifier IPR026258
- Description Signal recognition particle subunit SRP68
- Number of genes 159
- Gene duplication stats Loading...
- Associated GO terms GO:0030942 GO:0006614 GO:0008312 GO:0005047 GO:0005786
Abstract
The signal recognition particle (SRP) is a large ribonucleoprotein complex that targets secretory and membrane proteins to the endoplasmic reticulum membrane [ 1 ]. The mammalian SRP contains a 303-nucleotide SRP RNA and six proteins, named SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72. Among them, the two largest, SRP68 and SRP72, form a stable SRP68/72 heterodimer of unknown structure, which is required for sorting secretory proteins [ 2 ]. SRP68 binds to SRP RNA directly, while SRP72 binds the SRP RNA largely via non-specific electrostatic interaction. The binding of SRP72 with SRP RNA enhances the affinity of SRP68 for the RNA.
1. Protein-induced conformational changes of RNA during the assembly of human signal recognition particle. J. Mol. Biol. 367, 187-203
2. Characterization of the SRP68/72 interface of human signal recognition particle by systematic site-directed mutagenesis. Protein Sci. 18, 2183-95