InterPro domain: IPR026122

MOV-10 (moloney leukemia virus 10 protein) is the human homologue of Drosophila melanogaster Armitage (armi). Human MOV-10 is a 5' to 3' RNA helicase required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC) [ 1 , 2 , 3 ]. It has been shown to interact with fragile X mental retardation protein FMRP and regulates miRNA-mediated translational repression by AGO2 [ 4 ]. Interestingly, it interacts with retrotransposons and acts as a potent inhibitor of retrotransposition in cells [ 5 ].

MOV-10 is required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). It interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription [ 6 ].

1. MicroRNA silencing through RISC recruitment of eIF6. Nature 447, 823-8
2. RISC assembly defects in the Drosophila RNAi mutant armitage. Cell 116, 831-41
3. MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs. Mol. Cell 54, 573-85
4. MOV10 and FMRP regulate AGO2 association with microRNA recognition elements. Cell Rep 9, 1729-1741
5. MOV10 RNA helicase is a potent inhibitor of retrotransposition in cells. PLoS Genet. 8, e1002941
6. Capped small RNAs and MOV10 in human hepatitis delta virus replication. Nat. Struct. Mol. Biol. 15, 714-21