InterPro domain: IPR026057

General Information

  • Identifier IPR026057
  • Description PC-Esterase
  • Number of genes 6295
  • Gene duplication stats Loading...

Abstract

The PC-Esterase family [ 1 ] is comprised of Cas1p, the Homo sapiens C7orf58, Arabidopsis thaliana PMR5 and a group of plant freezing resistance/cold acclimatization proteins typified by Arabidopsis thaliana ESKIMO1 [ 2 , 3 ], animal FAM55D proteins, and animal FAM113 proteins. The PC-Esterase family has features that are both similar and different from the canonical GDSL/SGNH superfamily [ 4 ]. The members of this family are predicted to have Acyl esterase activity and predicted to modify cell-surface biopolymers such as glycans and glycoproteins [ 4 , 4 ]. The Cas1p protein has a Cas1_AcylT domain, in addition, with the opposing acyltransferase activity [ 4 ]. The C7orf58 family has a ATP-Grasp domain fused to the PC-Esterase and is the first identified secreted tubulin-tyrosine ligase like enzyme in eukaryotes [ 4 ]. The plant family with PMR5, ESK1, TBL3 etc have an N-terminal C rich potential sugar binding domain followed by the PC-Esterase domain [ 4 ].


1. Novel eukaryotic enzymes modifying cell-surface biopolymers. Biol. Direct 5, 1
2. Involvement of TBL/DUF231 proteins into cell wall biology. Plant Signal Behav 5, 1057-9
3. ESKIMO1 disruption in Arabidopsis alters vascular tissue and impairs water transport. PLoS ONE 6, e16645

Species distribution

Gene table

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