InterPro domain: IPR026010
General Information
- Identifier IPR026010
- Description Nucleoporin NSP1/NUP62
- Number of genes 134
- Gene duplication stats Loading...
- Associated GO terms GO:0017056 GO:0005643
Abstract
NSP1 functions as a component of the nuclear pore complex (NPC). The 55-60 MDa NPC is composed of at least 31 different subunits. NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors [ 1 ].
NUP62 is a component of the p62 complex, composed of NUP62, NUP54, and the isoform p58 and isoform p45 of NUPL1 [ 2 ]. The p62 complex is an assembly of glycoproteins localised near the central gated channel of the nuclear pore complex.
1. Identification of genes encoding putative nucleoporins and transport factors in the fission yeast Schizosaccharomyces pombe: a deletion analysis. Yeast 21, 495-509
2. Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins. J. Cell Biol. 134, 589-601