InterPro domain: IPR025999

General Information

  • Identifier IPR025999
  • Description Microspherule protein, N-terminal domain
  • Number of genes 211
  • Gene duplication stats Loading...

Abstract

This domain is found in plants and higher eukaryotes, and is the N-terminal region of micro-spherule proteins which repress the transactivation activities of Nrf1 (p45 nuclear factor-erythroid 2 (p45 NF-E2)-related factor 1) [ 1 ]. In conjunction with DIPA the full-length protein acts as a transcription repressor [ 2 ]. The exact function of this domain is not known.


1. DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription. Exp. Mol. Pathol. 81, 184-90
2. MCRS2 represses the transactivation activities of Nrf1. BMC Cell Biol. 10, 9

Species distribution

Gene table