InterPro domain: IPR025986

This domain is found at the C terminus of the RNA-polymerase II-associated protein 3 (RPAP3). RPAP3 binds to Monad and is involved in regulating apoptosis [ 1 ]. This domain represents the potential Monad-binding region of RPAP3. RPAP3 contains TPR-repeats towards the N terminus. This domain is also found in other proteins with TPR-repeats at the N terminus, like sperm-associated antigen 1 [ 2 ], and in proteins without TPR-repeats.

1. Molecular cloning of novel Monad binding protein containing tetratricopeptide repeat domains. FEBS Lett. 582, 2365-70
2. Expression and function of the HSD-3.8 gene encoding a testis-specific protein. Mol. Hum. Reprod. 7, 811-8