InterPro domain: IPR025954

General Information

  • Identifier IPR025954
  • Description DBC1/CARP1 catalytically inactive NUDIX hydrolase domain
  • Number of genes 128
  • Gene duplication stats Loading...

Abstract

This entry represents the central conserved globular domain present in DBC1 and homologues, and is a catalytically inactive version of the Nudix hydrolase (MutT) domain [ 1 ]. It may have a role in binding NAD metabolites, such as ADP-ribose.

Deleted in breast cancer 1 (DBC1), also known as cell division cycle and apoptosis regulator protein 2 (CCAR2), and its paralogous cell division cycle and apoptosis regulator protein 1 (CCAR1) are large multi-domain proteins, with a nuclear or perinuclear localisation, and a role in promoting apoptosis upon processing by caspases [ 2 ].


1. Analysis of DBC1 and its homologs suggests a potential mechanism for regulation of sirtuin domain deacetylases by NAD metabolites. Cell Cycle 7, 1467-72

Species distribution

Gene table