InterPro domain: IPR025655
General Information
- Identifier IPR025655
- Description Peroxisomal membrane protein 14
- Number of genes 173
- Gene duplication stats Loading...
- Associated GO terms GO:0005778 GO:0005515 GO:0016560
Abstract
Peroxisomal membrane protein PEX14, or peroxin-14, is a core component of the peroxisomal translocation machinery or importomer [ 1 , 2 ]. PEX14 is involved in the docking of PEX5-bound protein onto the peroxisomal membrane, and it may be involved in the translocation step into the peroxisome matrix [ 3 ]. In addition to its role in protein docking, a role in transcriptional regulation has also been suggested for PEX14 [ 4 ].
1. PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. J. Cell Biol. 148, 931-44
2. Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19. EMBO J. 28, 745-54
3. Pex14p, more than just a docking protein. Biochim. Biophys. Acta 1763, 1574-84
4. NAPP2, a peroxisomal membrane protein, is also a transcriptional corepressor. Genomics 79, 423-31