InterPro domain: IPR025609

The Lsm14 N-terminal domain is a type of LSM domain found in Lsm14 proteins (also known as Rap55) [ 1 , 2 ] and in the Saccharomyces cerevisiae homologue Scd6 [ 3 ]. The domain is also found in the human EDC3 protein (enhancer of mRNA-decapping protein 3) where it is fused to the the Rossmanoid YjeF-N domain [ 4 ]. In addition, both EDC3 and Scd6 are found fused to the FDF domain [ 5 , 5 ].

1. RAP55, a cytoplasmic mRNP component, represses translation in Xenopus oocytes. J. Biol. Chem. 281, 40096-106
2. RAP55: insights into an evolutionarily conserved protein family. Int. J. Biochem. Cell Biol. 41, 977-81
3. Novel Sm-like proteins with long C-terminal tails and associated methyltransferases. FEBS Lett. 569, 18-26
4. Novel conserved domains in proteins with predicted roles in eukaryotic cell-cycle regulation, decapping and RNA stability. BMC Genomics 5, 45