InterPro domain: IPR025305

This is a repeated domain found in de-ubiquitinating proteins. It's exact function is not known, although it is likely to be involved in the binding of the Ubps in the complex with Rsp5 and Rup1 [ 1 , 2 ].

1. A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity. PLoS Biol. 8, 324-35
2. Hse1, a component of the yeast Hrs-STAM ubiquitin-sorting complex, associates with ubiquitin peptidases and a ligase to control sorting efficiency into multivesicular bodies. Mol. Biol. Cell 18