InterPro domain: IPR025257

General Information

  • Identifier IPR025257
  • Description Deubiquitinating enzyme MINDY-3/4, conserved domain
  • Number of genes 143
  • Gene duplication stats Loading...

Abstract

This is a conserved domain found in deubiquitinating enzymes, MINDY-3 and MINDY-4.

Deubiquitinating enzymes (DUBs) remove ubiquitin (Ub) from Ub-conjugated substrates to regulate the functional outcome of ubiquitylation. This entry includes MINDY-3/4. They belong to the MINDY (motif interacting with Ub-containing novel DUB) family (peptidase family C121), whose members are deubiquitinating enzymes releasing Lys48-linked ubiquitin [ 1 ].


1. MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes. Mol. Cell 63, 146-55

Species distribution

Gene table