InterPro domain: IPR024951

This domain is the catalytic domain of ATP-sulfurylase or sulphate adenylyltransferase ( 2.7.7.4 ). ATP-sulfurylase catalyses the synthesis of adenosine-phosphosulphate (APS) from ATP and inorganic sulphate [ 1 ]. Sometimes is found as part of a bifunctional polypeptide chain associated with adenylylsulphate kinase ( IPR002891 ). Both enzymes are required for PAPS (phosphoadenosine-phosphosulphate) synthesis from inorganic sulphate [ 2 ].

1. A member of a family of sulfate-activating enzymes causes murine brachymorphism. Proc. Natl. Acad. Sci. U.S.A. 95, 8681-5
2. A multifunctional Urechis caupo protein, PAPS synthetase, has both ATP sulfurylase and APS kinase activities. Gene 165, 243-8