InterPro domain: IPR024882
General Information
- Identifier IPR024882
- Description Nucleoporin p58/p45
- Number of genes 134
- Gene duplication stats Loading...
- Associated GO terms GO:0006913 GO:0017056 GO:0008139 GO:0005643
Abstract
Nucleoporin proteins p58 and p45 are components of the p62 complex, an assembly of four O-linked glycoproteins localised near the central gated channel of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane [ 1 ]. The p45 and p58 isoforms are generated by mRNA alternative splicing [ 2 ]. This entry also includes Nup58 protein from Drosophila melanogaster and Nup45 from Schizosaccharomyces pombe [ 3 ].
1. Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins. J. Cell Biol. 134, 589-601
2. cDNA cloning and analysis of the expression of nucleoporin p45. Gene 221, 245-53
3. Identification of genes encoding putative nucleoporins and transport factors in the fission yeast Schizosaccharomyces pombe: a deletion analysis. Yeast 21, 495-509