InterPro domain: IPR024880

Transport vesicles budding from the endoplasmic reticulum (ER) are coated with the COPII proteins [ 1 ]. Sec16 is involved in the initiation of assembly of the COPII coat and the selection of cargo molecules [ 2 , 3 , 4 , 5 , 6 ]. It is also involved in autophagy [ 7 ]. Two mammalian Sec16 homologues have been described and they seem to have nonredundant functions in ER export and transitional ER organisation [ 8 ].

1. COPII: a membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum. Cell 77, 895-907
2. Yeast SEC16 gene encodes a multidomain vesicle coat protein that interacts with Sec23p. J. Cell Biol. 131, 311-24
3. Distinct sets of SEC genes govern transport vesicle formation and fusion early in the secretory pathway. Cell 61, 723-33
4. SED4 encodes a yeast endoplasmic reticulum protein that binds Sec16p and participates in vesicle formation. J. Cell Biol. 131, 325-38
5. Selective packaging of cargo molecules into endoplasmic reticulum-derived COPII vesicles. Proc. Natl. Acad. Sci. U.S.A. 94, 837-42
6. Sec16p potentiates the action of COPII proteins to bud transport vesicles. J. Cell Biol. 158, 1029-38
7. Autophagosome requires specific early Sec proteins for its formation and NSF/SNARE for vacuolar fusion. Mol. Biol. Cell 12, 3690-702
8. Two mammalian Sec16 homologues have nonredundant functions in endoplasmic reticulum (ER) export and transitional ER organization. Mol. Biol. Cell 18, 839-49