InterPro domain: IPR024875
General Information
- Identifier IPR024875
- Description Protein Lines
- Number of genes 116
- Gene duplication stats Loading...
Abstract
In Drosophila, Lines is a segment polarity protein and a modulator of the Abd-B HOX protein. Lines is needed for Abd-B to activate its downstream targets cut, spalt and ems, which are involved in posterior spiracle morphogenesis [ 1 , 2 , 3 , 4 , 5 ].
1. Tissue- and stage-specific modulation of Wingless signaling by the segment polarity gene lines. Genes Dev. 14, 1364-76
2. The roles of hedgehog, wingless and lines in patterning the dorsal epidermis in Drosophila. Development 122, 1083-92
3. The lines gene of Drosophila is required for specific functions of the Abdominal-B HOX protein. Development 125, 1269-74
4. drumstick, bowl, and lines are required for patterning and cell rearrangement in the Drosophila embryonic hindgut. Dev. Biol. 240, 611-26
5. The Drm-Bowl-Lin relief-of-repression hierarchy controls fore- and hindgut patterning and morphogenesis. Mech. Dev. 120, 1139-51