InterPro domain: IPR024789
General Information
- Identifier IPR024789
- Description Anaphase-promoting complex subunit 4
- Number of genes 142
- Gene duplication stats Loading...
- Associated GO terms GO:0030071 GO:0005680 GO:0031145
Abstract
The anaphase-promoting complex (APC) or cyclosome is a multi-subunit E3 protein ubiquitin ligase that regulates important events in mitosis, such as the initiation of anaphase and exit from telophase. The APC, in conjunction with other enzymes, assembles multi-ubiquitin chains on a variety of regulatory proteins, thereby targeting them for proteolysis by the 26S proteasome [ 1 ].
This family represents the anaphase-promoting complex subunit 4 (APC4). This entry also includes APC4 homologue, EMB-30, from Caenorhabditis elegans [ 2 ].
1. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. Cell 133, 653-65
2. EMB-30: an APC4 homologue required for metaphase-to-anaphase transitions during meiosis and mitosis in Caenorhabditis elegans. Mol. Biol. Cell 11, 1401-19