InterPro domain: IPR024738
General Information
- Identifier IPR024738
- Description Transcriptional coactivator Hfi1/Transcriptional adapter 1
- Number of genes 532
- Gene duplication stats Loading...
- Associated GO terms GO:0070461
Abstract
The yeast Spt-Ada-Gcn5-Acetyl (SAGA) transferase complex is a multifunctional coactivator involved in multiple cellular processes [ 1 ], including regulation of transcription by RNA polymerase II [ 2 , 3 ]. It is formed of five major modular subunits and shows a high degree of structural conservation to human TFTC and STAGA [ 4 ]. This entry represents Hfi1 (known as Transcriptional adapter 1, Tada1 in higher eukaryotes), one of the subunits that constitute the SAGA core. It also functions as a component of the SALSA and SLIK complexes.
1. The SAGA continues: expanding the cellular role of a transcriptional co-activator complex. Oncogene 26, 5329-40
2. NET1 and HFI1 genes of yeast mediate both chromosome maintenance and mitochondrial rho(-) mutagenesis. Yeast 20, 955-71
3. Molecular architecture of the S. cerevisiae SAGA complex. Mol. Cell 15, 199-208
4. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. Mol. Cell. Biol. 21, 6782-95