InterPro domain: IPR024668

General Information

  • Identifier IPR024668
  • Description GA-binding protein alpha subunit, N-terminal
  • Number of genes 4
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Abstract

GA-binding protein alpha is a transcription factor capable of interacting with purine rich repeats (GA repeats). This N-terminal domain found in the transcription factor GABP alpha consists of a five-stranded beta-sheet crossed by a distorted helix and has been termed OST domain. The surface of the GABP alpha OST domain contains two clusters of negatively-charged residues suggesting there are positively-charged partner proteins. The OST domain binds to the CH1 and CH3 domains of the co-activator histone acetyltransferase CBP/p300 [ 1 ].


1. Identification and structural characterization of a CBP/p300-binding domain from the ETS family transcription factor GABP alpha. J. Mol. Biol. 377, 636-46

Species distribution

Gene table