InterPro domain: IPR024652

This family consists of several fungal trichodiene synthase proteins ( 4.2.3.6 ). TRI5 encodes the enzyme trichodiene synthase, which has been shown to catalyse the first step in the trichothecene pathways of Fusarium and Trichothecium species [ 1 , 2 ].

Proteins in this entry also includes COP6 from Coprinopsis cinerea and CLM1 from Gibberella zeae. COP6 is an alpha-cuprenene synthase involved in the biosynthesis of alpha-cuprenene and oxidized derivatives [ 3 ]. CLM1 is a longiborneol synthase required for culmorin production [ 4 ].

1. Characterization of the gene cluster for biosynthesis of macrocyclic trichothecenes in Myrothecium roridum. Mol. Gen. Genet. 257, 421-32
2. Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade. Proc. Natl. Acad. Sci. U.S.A. 98, 13543-8
3. Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus. Mol. Microbiol. 72, 1181-95
4. CLM1 of Fusarium graminearum encodes a longiborneol synthase required for culmorin production. Appl. Environ. Microbiol. 76, 136-41