InterPro domain: IPR024610
General Information
- Identifier IPR024610
- Description Inhibitor of growth protein, N-terminal histone-binding
- Number of genes 241
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Abstract
Histones undergo numerous post-translational modifications, including acetylation and methylation, at residues which are then probable docking sites for various chromatin remodelling complexes. Inhibitor of growth proteins (INGs) specifically bind to residues that have been thus modified. INGs carry a well-characterised C-terminal PHD-type zinc-finger domain, binding with lysine 4-tri-methylated histone H3 (H3K4me3), as well as this N-terminal domain that binds unmodified H3 tails. Although these two regions can bind histones independently, together they increase the apparent association of the ING for the H3 tail.
This entry represents the N-terminal histone binding domain found in inhibitor proteins.
Species distribution
Gene table
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