InterPro domain: IPR024576
General Information
- Identifier IPR024576
- Description Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381
- Number of genes 158
- Gene duplication stats Loading...
Abstract
This uncharacterised domain is found in eukaryotic rRNA methyltransferases like yeast Spb1 and mammalian homologue Ftsj3. Spb1 is required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit [ 1 , 2 ].
1. Spb1p is a putative methyltransferase required for 60S ribosomal subunit biogenesis in Saccharomyces cerevisiae. Nucleic Acids Res. 27, 4598-608
2. Spb1p-directed formation of Gm2922 in the ribosome catalytic center occurs at a late processing stage. Mol. Cell 16, 663-9
Species distribution
Gene table
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