InterPro domain: IPR024576

General Information

  • Identifier IPR024576
  • Description Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381
  • Number of genes 158
  • Gene duplication stats Loading...

Abstract

This uncharacterised domain is found in eukaryotic rRNA methyltransferases like yeast Spb1 and mammalian homologue Ftsj3. Spb1 is required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit [ 1 , 2 ].


1. Spb1p is a putative methyltransferase required for 60S ribosomal subunit biogenesis in Saccharomyces cerevisiae. Nucleic Acids Res. 27, 4598-608
2. Spb1p-directed formation of Gm2922 in the ribosome catalytic center occurs at a late processing stage. Mol. Cell 16, 663-9

Species distribution

Gene table