InterPro domain: IPR024420

This entry represents Trs85, a subunit of the TRAPP III complex [ 1 ]. Trs85 is a multimeric guanine nucleotide-exchange factor for Ypt1, required for membrane expansion during autophagy and the CVT pathway. It directs Ypt1 to the phagophore assembly site [ 2 , 3 , 4 , 5 ].

1. Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy. Proc. Natl. Acad. Sci. U.S.A. 107, 7811-6
2. Yeast meiotic mutants proficient for the induction of ectopic recombination. Genetics 148, 581-98
3. GSG1, a yeast gene required for sporulation. Yeast 11, 1147-55
4. Trs85 is required for macroautophagy, pexophagy and cytoplasm to vacuole targeting in Yarrowia lipolytica and Saccharomyces cerevisiae. Autophagy 1, 37-45
5. Trs85 (Gsg1), a component of the TRAPP complexes, is required for the organization of the preautophagosomal structure during selective autophagy via the Cvt pathway. J. Biol. Chem. 280, 33669-78