InterPro domain: IPR024312

TACC proteins are present in different organisms, ranging from yeasts to mammals. Schizosaccharomyces pombe has one TACC protein, known as Alp7 or Mia1p [ 1 ]. Alp7/TACC consists of two domains: the N-terminal half that contains the nuclear localization signal (NLS) and has no homology to the other TACC members, and the C-terminal half, which consists of the conserved coiled-coil TACC domain [ 2 ]. Alp7/TACC forms a complex with Alp14/TOG and localizes to microtubules, SPBs and kinetochores [ 3 , 3 ]. This complex is necessary for mitotic and meiotic spindle assembly and proper chromosome segregation [ 4 ].

The homologue from S. cerevisiae, Slk19, also has a role in spindle assembly and stability, and it is required for proper chromosome segregation [ 5 , 6 ].

1. The TACC proteins: TACC-ling microtubule dynamics and centrosome function. Trends Cell Biol. 18, 379-88
2. Interdependency of fission yeast Alp14/TOG and coiled coil protein Alp7 in microtubule localization and bipolar spindle formation. Mol. Biol. Cell 15, 1609-22
3. Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpoint. EMBO J. 20, 3389-401
4. Targeting Alp7/TACC to the spindle pole body is essential for mitotic spindle assembly in fission yeast. FEBS Lett. 588, 2814-21
5. The yeast kinetochore protein Slk19 is required to prevent aberrant chromosome segregation in meiosis and mitosis. Genes Cells 7, 1033-42
6. Slk19p is a centromere protein that functions to stabilize mitotic spindles. J. Cell Biol. 146, 415-25