InterPro domain: IPR024298

Sec31 is a component of the COPII coat complex that mediates formation of transport vesicles from the ER. The central alpha-helical unit of Sec31 is structurally similar to four large architectural nucleoporins. This alpha-helical unit, common to COPII and nuclear pore complex proteins, has been termed the ancestral coatomer element 1 (ACE1) [ 1 ].

This entry represents the ACE1 element found in Sec31 and Sec16, which also contains an ACE1 [ 2 ]. The ACE1 element of Sec31 can functionally replace that of Sec16. Both Sec31 and Sec16 bind to Sec13 [ 3 ].

1. Structural evidence for common ancestry of the nuclear pore complex and vesicle coats. Science 322, 1369-73
2. Structure of the Sec13-Sec16 edge element, a template for assembly of the COPII vesicle coat. J. Cell Biol. 190, 347-61