InterPro domain: IPR024080

Thimet oligopeptidase and neurolysin are closely related zinc-dependent metallopeptidases that metabolize small bioactive peptides. They cleave many substrates at the same sites, but they recognise different positions on others [ 1 ].

This entry represents the up-down alpha bundle domain found at the N terminus of these and related M3 peptidases.

1. Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase. J. Biol. Chem. 282, 9722-32