InterPro domain: IPR024077

Thimet oligopeptidase and neurolysin are closely related zinc-dependent metallopeptidases that metabolize small bioactive peptides. They cleave many substrates at the same sites, but they recognise different positions onothers [ 1 ].

This entry represents an alpha orthogonal bundle domain found in these and related peptidases.

1. Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase. J. Biol. Chem. 282, 9722-32