InterPro domain: IPR023401

This entry represents the N-terminal domain of the ornithine cyclodeanimase family. This is an alpha/beta two layer sandwich domain. Members of this family includes ornithine cyclodeanimase [ 1 ], alanine dehydrogenase from Archaeoglobus [ 2 ] and human cytosolic 3,5,39-triiodo-L-thyronine-binding protein, also called mu-crystallin or CRYM [ 3 ]. The function of this domain in ornithine cyclodeaminases, in combination with the C terminus, is responsible for substrate binding. This is a dimerisation domain of alanine dehydrogenase and CRYM.

1. Ornithine cyclodeaminase: structure, mechanism of action, and implications for the mu-crystallin family. Biochemistry 43, 13883-91
2. Structure of alanine dehydrogenase from Archaeoglobus: active site analysis and relation to bacterial cyclodeaminases and mammalian mu crystallin. J. Mol. Biol. 342, 119-30
3. Crystal structure of human micro-crystallin complexed with NADPH. Protein Sci. 16, 329-35