InterPro domain: IPR023319

Tex (toxin expression) is a highly conserved bacterial protein involved in expression of critical toxin genes [ 1 ]. The overall structure is notably flat and elongated. The most striking structural feature is a long, central helix comprising from amino acid residue 274 to 322. The rest of the protein wraps around the central helix at both the N-terminal and C-terminal ends. Although the Tex structure is fairly compact, it can be largely described as a series of distinct domains [ 2 ].

This superfamily represents an N-terminal domain with a helix-turn-helix structure.

1. A new gene locus of Bordetella pertussis defines a novel family of prokaryotic transcriptional accessory proteins. J. Bacteriol. 178, 4445-52
2. Crystal structure and RNA binding of the Tex protein from Pseudomonas aeruginosa. J. Mol. Biol. 377, 1460-73