InterPro domain: IPR023296

This is a five-bladed beta-propeller fold catalytic domain where each blade has four twisted antiparallel beta-strands radially orientated around a pseudo-5-fold axis [ 1 ]. It can be found in the glycosyl hydrolase family 43 (GH43) members, including beta-xylosidases, alpha-L-arabinanases and bifunctional beta-xylosidases/alpha-L-arabinofuranosidases [ 2 , 3 , 4 ]. This domain can also be found in other GH families, such as GH32, GH62 and GH68 [ 5 ].

1. GH62 arabinofuranosidases: Structure, function and applications. Biotechnol. Adv.
2. Crystal structure of an inverting GH43 1,5-alpha-L-arabinanase from Geobacillus stearothermophilus complexed with its substrate. Biochem. J. 35, 792-804
3. Structural framework of fructosyl transfer in Bacillus subtilis levansucrase. Nat. Struct. Biol. 10, 935-41
4. The three-dimensional structure of invertase (beta-fructosidase) from Thermotoga maritima reveals a bimodular arrangement and an evolutionary relationship between retaining and inverting glycosidases. J. Biol. Chem. 279, 18903-10
5. Structural analysis of a glycoside hydrolase family 43 arabinoxylan arabinofuranohydrolase in complex with xylotetraose reveals a different binding mechanism compared with other members of the same family. Biochem. J. 418, 39-47