InterPro domain: IPR023247

Dynein-f, also known as dynein I1, is an inner-arm dynein complex comprising two different heavy chains together with a number of intermediate and light chains. In Chlamydomonas, IC97 is the intermediate chain of the Dynein-f complex. This entry includes IC97 ( C7A2A8 ) and its homologues, including CASC1 (also known as Dnai7) from humans [ 1 ].

The CAncer Susceptibility Candidate 1 (CASC1) gene is expressed in lung tissues, and is a strong candidate for the pulmonary adenoma susceptibility 1 (Pas1) locus, the major determinant of strain variation in lung tumour susceptibility [ 2 ]. There appears to be a strong correlation between functional polymorphism of CASC1 and lung tumour suspectibility in mice [ 3 ].

Different mouse strains fall into two genotype groups (susceptible and intermediate) according to differences in the 60th codon of the CASC1 gene [ 4 ]. The mouse CASC1 gene shares 81% similarity with the human equivalent; the role of CASC1 in human lung-cancer risk may nevertheless differ from that in mice [ 4 , 4 ].

1. Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat. J Mol Cell Biol 11, 383-394
2. A V141L polymorphism of the human LRMP gene is associated with survival of lung cancer patients. Carcinogenesis 27, 1386-90
3. Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice. Proc. Natl. Acad. Sci. U.S.A. 100, 12642-7