InterPro domain: IPR023241

Members of protein family FAM175 include the BRCA1-A complex subunit Abraxas 1 [ 1 , 2 ], BRISC complex subunit Abraxas 2 or Abro1 (Abraxas brother protein 1) [ 3 , 4 ], and uncharacterised plant proteins.

It is thought that BRCA1-A complex subunit Abraxas acts as a central scaffold protein responsible for assembling the various components of the BRCA1-A complex, and mediates recruitment of BRCA1 [ 5 , 5 ]. Similarly, Abro1 probably acts as a scaffold facilitating assembly of the various components of BRISC [ 5 ] - the protein does not interact with BRCA1, but binds polyubiquitin [ 5 ]. The primary sequences of these proteins contain an MPN-like domain [ 5 ].

This entry represents the plant members of FAM175.

1. Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science 316, 1194-8
2. Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. Proc. Natl. Acad. Sci. U.S.A. 104, 20759-63
3. K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1. EMBO J. 28, 621-31
4. NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. Genes Dev. 23, 729-39