InterPro domain: IPR023167

The transcription factor Yap1 is a central regulator of the response to oxidative stress in Saccharomyces cerevisiae. In the active oxidized form, a nuclear export signal (NES) in the carboxy-terminal cysteine-rich domain is masked by disulphide-bond-mediated interactions with a conserved amino-terminal alpha-helix. Upon reduction of the disulphide bonds, Yap1 undergoes a change that exposes the NES and allows redistribution to the cytoplasm [ 1 ]. This entry represents a redox-regulated domain superfamily of Yap1.

1. Structural basis for redox regulation of Yap1 transcription factor localization. Nature 430, 917-21