InterPro domain: IPR022927

This entry represents an RNA pyrophosphohydrolase belonging to the nudix hydrolase family, RppH subfamily. It accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage [ 1 ].

1. The bacterial enzyme RppH triggers messenger RNA degradation by 5' pyrophosphate removal. Nature 451, 355-8