InterPro domain: IPR022783

This entry represents the C-terminal domain of GCF2 its homologues [ 1 , 2 ], as well as in a number of other proteins including Tuftelin-interacting protein 11 [ 3 ]. While the function of the domain is unknown, some of the proteins it is found in are reported to be involved in pre-mRNA splicing [ 4 , 4 ]. This domain is also found in Sip1, a septin interacting protein [ 5 ].

1. Identification of a novel component C2ORF3 in the lariat-intron complex: lack of C2ORF3 interferes with pre-mRNA splicing via intron turnover pathway. Genes Cells 19, 78-87
2. Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism. Cell Stem Cell 11, 231-41
3. Isolation and characterization of post-splicing lariat-intron complexes. Nucleic Acids Res. 37, 891-902
4. NTR1 is required for transcription elongation checkpoints at alternative exons in Arabidopsis. EMBO J. 34, 544-58
5. Identification of septin-interacting proteins and characterization of the Smt3/SUMO-conjugation system in Drosophila. J. Cell. Sci. 115, 1259-71