InterPro domain: IPR022709

General Information

  • Identifier IPR022709
  • Description Protein SCAI
  • Number of genes 293
  • Gene duplication stats Loading...
  • Associated GO terms GO:0003714   GO:0006351  

Abstract

SCAI is a transcriptional cofactor and tumour suppressor that suppresses MKL1-induced SRF transcriptional activity. It may function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1 [ 1 ].


1. SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin. Nat. Cell Biol. 11, 557-68

Species distribution

Gene table