InterPro domain: IPR022702
General Information
- Identifier IPR022702
- Description DNA (cytosine-5)-methyltransferase 1, replication foci domain
- Number of genes 384
- Gene duplication stats Loading...
Abstract
This domain is part of a cytosine specific DNA methyltransferase enzyme (DNMT). It functions non-catalytically to target the protein towards replication foci. This allows the DNMT1 protein to methylate the correct residues. This domain targets DMAP1 and HDAC2 to the replication foci during the S phase of mitosis. They are thought to have some importance in conversion of critical histone lysine moieties [ 1 ].
A structure exists for the human cytosine specific DNA methyltransferase replication foci domain [ 2 ].
1. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nat. Genet. 25, 269-77
2. The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1. J. Biol. Chem. 286, 15344-51