InterPro domain: IPR022577

This region is found in eukaryotes, and is typically between 182 and 199 amino acids in length. There is a single completely conserved residue R that may be functionally important. Tubulin folding cofactor D does not co-polymerise with microtubules either in vivo or in vitro, but instead modulates microtubule dynamics by sequestering beta-tubulin from GTP-bound alphabeta-heterodimers in microtubules [ 1 ].

1. Tubulin folding cofactor D is a microtubule destabilizing protein. FEBS Lett. 470, 93-5