InterPro domain: IPR022495

General Information

  • Identifier IPR022495
  • Description Serine/threonine-protein kinase Bud32
  • Number of genes 156
  • Gene duplication stats Loading...
  • Associated GO terms GO:0004674  

Abstract

Serine/threonine-protein kinase Bud32 is conserved from Archaea to human. In many Archaeal genomes, Kae1 and Bud32 are fused [ 1 ]. The complex is homologous to the Kae1 and Bud32 subunits of the eukaryotic KEOPS complex (composed of Bud32, Kae1, Cgi121, Pcc1 and Gon7), an apparently ancient protein kinase-containing molecular machine that is essential for t6A tRNA modification [ 2 , 3 ].


1. Structure of the archaeal Kae1/Bud32 fusion protein MJ1130: a model for the eukaryotic EKC/KEOPS subcomplex. EMBO J. 27, 2340-51
2. The universal Kae1 protein and the associated Bud32 kinase (PRPK), a mysterious protein couple probably essential for genome maintenance in Archaea and Eukarya. Biochem. Soc. Trans. 37, 29-35
3. The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A. EMBO J. 30, 873-81

Species distribution

Gene table