InterPro domain: IPR022485

General Information

  • Identifier IPR022485
  • Description 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
  • Number of genes 20
  • Gene duplication stats Loading...
  • Associated GO terms GO:0009234   GO:0070205  

Abstract

This protein catalyzes the formation of SHCHC, or (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, by elmination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) [ 1 ]. Note that SHCHC synthase activity previously was attributed to MenD, which in fact is SEPHCHC synthase.


1. Identification and characterization of (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase in the menaquinone biosynthesis of Escherichia coli. Biochemistry 47, 3426-34

Species distribution

Gene table