InterPro domain: IPR022383
General Information
- Identifier IPR022383
- Description Lactate/malate dehydrogenase, C-terminal
- Number of genes 1264
- Gene duplication stats Loading...
- Associated GO terms GO:0016616
Abstract
L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis [ 1 ]. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate [ 2 ]. The enzyme participates in the citric acid cycle.
This entry represents the C-terminal, and is thought to be an is an unusual alpha+beta fold.
1. Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase. Proteins 43, 175-85
2. Refined crystal structure of mitochondrial malate dehydrogenase from porcine heart and the consensus structure for dicarboxylic acid oxidoreductases. Biochemistry 33, 2078-88