InterPro domain: IPR022238
General Information
- Identifier IPR022238
- Description 18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23, C-terminal
- Number of genes 135
- Gene duplication stats Loading...
- Associated GO terms GO:0070476 GO:0016435
Abstract
This entry represents the C-terminal domain of 18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 [ 1 ]. Bud23 homologues can be found from yeast to human. They are S-adenosyl-L-methionine-dependent methyltransferases that specifically methylates the N7 position of a guanine in 18S rRNA [ 2 ]. Bud23 homologue in Arabidopsis, known as Rid2 (ROOT INITIATION DEFECTIVE 2), is also involved in pre-rRNA processing [ 3 ].
In humans, Bud23 is located in the Williams-Beuren syndrome (WBS) critical region [ 4 ].
1. Bud23 methylates G1575 of 18S rRNA and is required for efficient nuclear export of pre-40S subunits. Mol. Cell. Biol. 28, 3151-61
2. The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis. Mol. Biol. Cell 26, 2080-95
3. Genetic identification of Arabidopsis RID2 as an essential factor involved in pre-rRNA processing. Plant J. 67, 49-60
4. Characterization of two novel genes, WBSCR20 and WBSCR22, deleted in Williams-Beuren syndrome. Cytogenet. Cell Genet. 95, 20-7