InterPro domain: IPR022214

MOZART1 or Mzt1 is a component of the gamma-tubulin complex and is required for its recruitment to the microtubule organizing centre in humans and yeast [ 1 , 2 , 3 ]. This function is conserved in plant homologues, known as gamma-tubulin complex protein 3 (GCP3)-interacting proteins (GIPs) [ 4 , 5 ]. Studies in plant homologues GIP1 and GIP2 indicate that they play a major role in nuclear envelope shaping in both cycling and differentiated cells [ 6 ] and that they are essential for centromere architecture [ 7 , 8 ].

1. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science 328, 593-9
2. Mzt1/Tam4, a fission yeast MOZART1 homologue, is an essential component of the γ-tubulin complex and directly interacts with GCP3(Alp6). Mol. Biol. Cell 24, 3337-49
3. Fission yeast MOZART1/Mzt1 is an essential γ-tubulin complex component required for complex recruitment to the microtubule organizing center, but not its assembly. Mol. Biol. Cell 24, 2894-906
4. Identification of a novel small Arabidopsis protein interacting with gamma-tubulin complex protein 3. Cell Biol. Int. 32, 546-8
5. Arabidopsis GCP3-interacting protein 1/MOZART 1 is an integral component of the γ-tubulin-containing microtubule nucleating complex. Plant J. 71, 216-25
6. GIP/MZT1 proteins orchestrate nuclear shaping. Front Plant Sci 5, 29
7. Arabidopsis MZT1 homologs GIP1 and GIP2 are essential for centromere architecture. Proc. Natl. Acad. Sci. U.S.A. 112, 8656-60
8. GIP/MZT1 proteins: Key players in centromere regulation. Cell Cycle 14, 3665-6