InterPro domain: IPR022159

This domain is found in septin and tuftelin-interacting protein (STIP) and tuftelin-interacting protein 11 (TFIP11). STIP is essential for embryogenesis in Caenorhabditis elegans [ 1 ]. Tuftelin-interacting protein 11 is a component of the spliceosome involved in spliceosome disassembly [ 2 ]. TFIP11 was first identified in a yeast two-hybrid screening as a protein interacting with tuftelin, one of the presumed enamel matrix proteins [ 3 ].

1. Characterization of STIP, a multi-domain nuclear protein, highly conserved in metazoans, and essential for embryogenesis in Caenorhabditis elegans. Exp. Cell Res. 313, 1460-72
2. Identification of a novel nuclear localization signal and speckle-targeting sequence of tuftelin-interacting protein 11, a splicing factor involved in spliceosome disassembly. Biochem. Biophys. Res. Commun. 390, 1044-50
3. Identification of tuftelin- and amelogenin-interacting proteins using the yeast two-hybrid system. Connect. Tissue Res. 38, 257-67;discussion 295-303