InterPro domain: IPR022125
General Information
- Identifier IPR022125
- Description U3 small nucleolar RNA-associated protein 10, N-terminal
- Number of genes 109
- Gene duplication stats Loading...
Abstract
This entry represents the N-terminal domain of Utp10, which is a HEAT-repeat containing protein involved in nucleolar processing of pre-18S ribosomal RNA [ 1 ]. Utp10 is also involved in 40S ribosome maturation [ 2 ]. Proteins containing this domain also include HEATR1 from humans. HEATR1 is required for optimal pre-ribosomal RNA transcription by RNA polymerase I [ 3 ].
1. A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis. Nature 417, 967-70
2. Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation. RNA 13, 1516-27
3. Recruitment of factors linking transcription and processing of pre-rRNA to NOR chromatin is UBF-dependent and occurs independent of transcription in human cells. Genes Dev. 21, 2041-54