InterPro domain: IPR022031

This domain is found in N-terminal of the telomere-associated protein,Rif1. In budding yeast, Rif1 is Recruited to telomeres by interaction with the C terminus of RAP1 is recruited to telomeres by interaction with the C terminus of RAP1 and negatively regulates telomere length by preventing telomere elongation or promoting degradation of the telomere ends [ 1 , 2 ]. In mammals, Rif1 is required for checkpoint mediated arrest of cell cycle progression in response to DNA damage during S-phase (the intra-S-phase checkpoint) [ 3 ].

1. A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation. Genes Dev. 6, 801-14
2. A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae. Genes Dev. 11, 748-60
3. Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes Dev. 18, 2108-19